Shown is a fibroblast from a Hutchinson-Gilford Progeria syndrome patient which carries a mutation in the gene for lamin A (red), a major component of the nuclear lamina. Also shown is the distribution of nuclear pores (green) and a merged image. This passage 6 cell appears much like the wildtype - after extended passaging, marked nuclear envelope abnormalities are seen in HGPS cells (seen in other images in this group). See Fig 2 in R.G. Goldman et al. 2004 Proc Natl Acad Sci 101:8963-8968.